Symbol
Name
ID

Ctnnb1
catenin beta 1
MGI:88276

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes	Nephroblastoma	Renal cell carcinoma
Disease(s) Associated with CTNNB1	Nephroblastoma	Renal cell carcinoma
colorectal cancer
nephroblastoma

Mouse Phenotypes

increased metanephric mesenchyme apoptosis

decreased kidney cell proliferation

squamous metaplasia of urethral gland

kidney cyst

increased urinary bladder carcinoma incidence

abnormal kidney morphology

decreased kidney collecting duct number

abnormal kidney development

absent nephrogenic zone

small kidney

renal hypoplasia

decreased nephron number

dilated renal tubule

absent kidney

fused kidneys

single kidney

abnormal foreskin morphology

hydroureter

ureter hypoplasia

abnormal urinary bladder morphology

abnormal urinary bladder urothelium morphology

impaired branching involved in ureteric bud morphogenesis

Availability

Mouse Genotype

Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt
Tg(Upk2-cre)6Xrw/0 (conditional)

Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt
Tcf21^tm1(cre)Seq/Tcf21⁺ (conditional)

Ctnnb1^tm2Kem/Ctnnb1^tm2Kem
Tg(Hoxb7-cre)5526Cmb/0 (conditional)

Ctnnb1^tm2Kem/Ctnnb1^tm2Kem
Tcf21^tm1(cre)Seq/Tcf21⁺ (conditional)

Ctnnb1^tm4Wbm/Ctnnb1^tm4Wbm
Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺ (conditional)

Ctnnb1^tm1Mmt/Ctnnb1⁺
Tg(Pbsn-cre)4Prb/0 (conditional)

Ctnnb1^tm1Mmt/Ctnnb1⁺
Tg(Upk2-cre)6Xrw/0 (conditional)

Ctnnb1^tm1Mmt/Ctnnb1⁺
Tg(Hoxb7-cre)13Amc/0 (conditional)

Ctnnb1^tm1Mmt/Ctnnb1⁺
Tg(Cdh16-cre)91Igr/0 (conditional)

Ctnnb1^tm1Mmt/Ctnnb1⁺
Tg(Msx2-rtTA)885Lma/0
Tg(tetO-cre)1Jaw/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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